Health

Health news, medical discoveries and wellness tips

Subcutaneous Tarlatamab Shows Promising Safety and Efficacy in Lung Cancer Trial
Health

Subcutaneous Tarlatamab Shows Promising Safety and Efficacy in Lung Cancer Trial

A Phase 1b trial of subcutaneous tarlatamab for extensive-stage small cell lung cancer (ES-SCLC) demonstrated a favorable safety profile with low rates of severe adverse events, including cytokine release syndrome (CRS). The new administration route showed comparable drug exposure to the intravenous form and preliminary antitumor activity, supporting further development.

Novartis's Pelacarsen Fails to Prevent Heart Attacks in Major Trial Despite Lowering Lp(a)
Health

Novartis's Pelacarsen Fails to Prevent Heart Attacks in Major Trial Despite Lowering Lp(a)

Novartis's experimental heart drug pelacarsen, widely anticipated to reduce heart attacks and strokes, has failed a large seven-year clinical trial. Despite significantly lowering lipoprotein(a) levels, the drug showed no benefit over placebo in preventing major cardiovascular events or deaths, disappointing cardiologists and raising questions about the direct causal link between Lp(a) and heart disease.